South Beach Grille is located at 7205 Estero Boulevard in Santini Marina Plaza at the south end of Fort Myers Beach.

From Bonita Springs,
Take BONITA BEACH RD SE (CR-865 W) - Go 2.5 miles. 
Continue on HICKORY BLVD (CR-865 W) - Go 2.1 miles.
Continue on ESTERO BLVD (CR-865) - Go 5.3 miles. 
Arrive at 7205 ESTERO BLVD, FORT MYERS BEACH, on the Right.

From Fort Myers,
Take SUMMERLIN RD (SR-869 S) to SAN CARLOS BLVD (SR-865).
Turn left on SAN CARLOS BLVD (SR-865) - go 2.9 miles.
Bear left on ESTERO BLVD (CR-865) - go 4.7 miles.
Arrive at 7205 ESTERO BLVD, FORT MYERS BEACH, on the Left.